Prospects for minocycline neuroprotection.

ONLINE FIRST NEUROLOGICAL REVIEW Prospects for Minocycline Neuroprotection

M inocycline is a clinically available antibiotic and anti-inflammatory drug that also demonstrates neuroprotective properties in a variety of experimental models of neurological diseases. There have thus far been more than 300 publications on minocycline neuroprotection, including a growing number of human studies. Our objective is to critically review the biological basis and translational po...

Minocycline Provides Neuroprotection

Additive neuroprotective effects of minocycline with creatine in a mouse model of ALS.

The known neuroprotective effects of minocycline and creatine in animal models of amyotrophic lateral sclerosis (ALS) led us to examine whether the combination of these agents would result in increased neuroprotection. As previously reported, we confirmed in ALS mice that either minocycline or creatine treatment results in improvement in motor performance and extended survival. We report that c...

Experimental models of neuroprotection relevant to multiple sclerosis.

Activated T cells, particularly those of the T-helper (Th) 1 subset, have the capacity to kill neurons. Strategies for preventing such damage may include deviation of activated T cells into the Th2 subset (e.g., via use of glatiramer acetate), alteration of functional properties of Th1 cells (e.g., through use of interferon [INF]-beta or IV immunoglobulin), and inhibition of activated cell migr...

Minocycline and magnesium in combination attenuates oxidative stress and decreases ischemic neuronal damage in vivo

A neuroprotective strategy through a combination therapy is always being superior to any other singular therapeutic interventions, as these acts through a multifaceted approach within the brain during focal cerebral ischemia. Therefore, the development of a potential new combination of drug which can bring about desirable improved neuroprotection targeting different pathways against ischemic st...